Human papillomavirus infection plays a role in conjunctival squamous cell carcinoma: a systematic review and meta-analysis of observational studies
Ingvild Ramberg, Michael Møller-Hansen, Peter Bjerre Toft, Mikkel Funding, Steffen Heegaard
Read MoreConjunctival intraepithelial neoplasia and carcinoma: distinct clinical and histological features in relation to human papilloma virus status
Ingvild Ramberg, Peter Bjerre Toft, Jeanette Bæhr Georgsen, Volkert Dirk Siersma, Mikkel Funding, David Hebbelstrup Jensen, Christian von Buchwald, Steffen Heegaard
Read MoreConjunctival intraepithelial neoplasia and carcinoma: distinct clinical and histological features in relation to human papilloma virus status
Ingvild Ramberg, Peter Bjerre Toft, Jeanette Bæhr Georgsen, Volkert Dirk Siersma, Mikkel Funding, David Hebbelstrup Jensen, Christian von Buchwald, Steffen Heegaard
Read MoreHigh-risk human papillomavirus positive primary squamous cell carcinoma of the lacrimal gland: a case report
Jiawei Zhao, Harry Quon, Wayne Koch, Lisa M Rooper & Ashley A Campbell
Read MoreHuman papillomavirus in ocular malignant tumours: a study from a tertiary eye care centre in North India
Sheetal Chauhan, Seema Sen, Neeta Singh, Anjana Sharma, Neelam Pushker, Seema Kashyap, Bhavna Chawla
Read MoreObjective
The present study aims to detect the presence of human papillomavirus (HPV) in ocular malignant tumours, including retinoblastoma, eyelid squamous cell carcinoma (SCC), and sebaceous gland carcinoma (SGC), in the North Indian population.
Design
Prospective observational non randomized study.
Participants
In this study, 142 prospective cases of ocular malignant tumours (retinoblastoma, SGC, and SCC) were included.
Methods
HPV was detected by multiplex PCR using PGMY09/11 primers in 142 patients with ocular malignancies. This was followed by genotyping using linear array (reverse hybridization).
Results
Of the 142 tumours studied, 72 were retinoblastoma, 30 SGC, and 40 SCC. The HPV genome was detected in 2.8% (4 of 142) of cases by multiplex PCR; all positive cases (4 of 40) were SCC. Genotyping revealed that all positives belonged to the high-risk HPV16 genotype. HPV-positive SCC patients had better disease-free survival. Retinoblastoma and SGC cases were negative for HPV.
Conclusions
Low prevalence of HPV in ocular malignancies was observed in this study. The HPV genome was detected only in ocular squamous cell carcinoma cases and these patients were associated with better prognosis. HPV may not have a role in retinoblastoma and SGC in the North Indian population.
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canadianjournalofophthalmology.ca/article/S0008-4182(18)30909-8/fulltext
Targeted genome sequencing of negative and positive human papillomavirus induced conjunctival carcinomas
Ingvild Ramberg, Peter Toft, David Jensen, Christian von Buchwald, Finn Cilius Nielsen, Mikkel Funding, Steffen Heegaard
Read Morehttps://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2019.5336
Squamous cell carcinoma in the anophthalmic socket: a series of four cases with HPV-16 profiling
Lindsay A McGrath, Sachin Madhusudan Salvi, Soupramanien Sandramouli, Rina Bhatt, Kate Cuschieri, Hardeep Singh Mudhar
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