Papillary carcinoma of the thyroid gland (PCTG) constitutes 80%–85% of thyroid cancers globally. Despite early lymphatic invasion, PCTG has a relatively indolent course and rarely metastasizes outside of the neck.

Metastasis to the brain from PCTG is even more uncommon and usually occurs in the context of widely disseminated disease. While the mainstay of treatment for intracranial metastasis from PCTG includes surgical excision and radiotherapy, recent advances into our understanding of the molecular pathways governing PCTG have facilitated development of novel targeted chemotherapeutics. We present a case of superior oblique myositis that was presumed secondary to treatment of widely metastatic PCTG with dabrafenib and trametinib therapy. To our knowledge this is the first such case in the English language ophthalmic literature.

https://www.canadianjournalofophthalmology.ca/article/S0008-4182(21)00032-6/fulltext