Ediriwickrema, Lilangi S.; Liu, Catherine Y.; Kikkawa, Don O.; Korn, Bobby S.
The authors describe a clinical case whereby a patient with metastatic cutaneous melanoma developed eyelash poliosis after undergoing treatment with combination immunotherapy with ipilimumab and nivolumab.
Sunali Goyal, Sami H. Uwaydat
A 50-year-old man diagnosed with colon cancer and liver metastasis, underwent extensive chemotherapy with m-FOLFOX6 combined with avastin, hemicolectomy, segmental liver resection followed by addition of multiple cycles of Panitumumab (epidermal growth factor inhibitor [EGFR]). A baseline eye examination before initiation of another drug revealed hyperemia of face with papulopustular lesions (black arrow) similar to rosacea lesions. The eyebrows were found to be thick and rigid (blue arrow). Slit lamp examination revealed elongated and thickened eyelashes (trichomegaly) with curled terminal ends (red arrow). Furthermore, poliosis (whitening) of several eyelashes and brow hair was noted bilaterally. (Magnified version of Fig 1 is available online at www.aaojournal.org.)